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25. 12月 2004
Oregon State University
biology.science.oregonstate.edu
Biology Program Information
WEST NILE VIRUS IN THE UNITED STATES
– Yellow Fever. Gottfried Helnwein. Leid macht stark 1974 ... Gottfried Helnwein. Der höhnische Arzt (The Mocking Physician)1973 ...
Family: Flaviviridae - Pestiviruses – Bovine viral diarrhea viruses 1 & 2 (BVDV- 1, BVDV-2) – Hog Cholera/classical swine fever (CSFV) • Hapaciviruses – Hepatitis C virus (HCV) • Flaviviruses – Rio Bravo – TBEV (tick-borne encephalitis) – JE (Japanese Encephalitis) – Dengue (types 1-4) – Yellow Fever |
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Helnwein - Leid macht stark
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Family: Flaviviridae - Pestiviruses
– Bovine viral diarrhea viruses 1 & 2 (BVDV- 1, BVDV-2) – Hog Cholera/classical swine fever (CSFV) • Hapaciviruses – Hepatitis C virus (HCV) • Flaviviruses – Rio Bravo – TBEV (tick-borne encephalitis) – JE (Japanese Encephalitis) – Dengue (types 1-4) – Yellow Fever |
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Gottfried Helnwein
Leid macht stark 1974 |
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Flaviviridae Family Phylogeny
Flavivirus genus (visible version) Primary flavivirus transmission vector is the Culex mosquito General life cycle of genus Flavivirus viruses Flaviviruses are (+) sense RNA viruses with no nucleoinvasive replication processes. Flavivirus Genome and Translated Protein Coding Regions Conserved RNA Structures in general Flavivirus genome *from Annu. Rev. Microbiol. 2002 56:371-402 Flavivirus Nucleocapsid • Map indicates states reporting laboratory-positive West Nile virus infection in birds, mosquitoes, animals, or humans during 2002. West Nile Virus in the United States as of February 25, 2004* • Map indicates human cases (in red) during 2003 until Feb. 25, 2004. • Colorado highest w/ 2477 cases, Nebraska next w/ 1867 cases. WNV phylogenetic tree based on E-glycoprotein nucleic acid sequence data (255 base pairs). |
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Gottfried Helnwein
Der höhnische Arzt (The Mocking Physician)1973 |
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Gottfried Helnwein
Guten Morgen, Du Sau! (Good Morning, You Bastard!) 1972 Gottfried Helnwein, Earthquake, 1977 |
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WNV Genome Structure
• The genome is not segmented and consists of a single molecule of linear positive- sense single-stranded RNA. The complete genome is 10488–10976 nucleotides long. The 5'–end of the genome has a cap methylated nucleotide cap. The 3'–terminus has no poly (A) tract, or a poly (A) tract (in case of some strains of tick-borne encephalitis complex of flaviviruses). * Büchen-Osmond, C. (Ed), (2003). 00.026.0.01. Flavivirus. In: ICTVdB - The Universal Virus Database, version 3. ICTVdB Management, The Earth Institute, Biosphere 2 Center, Columbia University, Oracle, AZ, USA Replication of WNV in Host Cell *from Annu. Rev. Microbiol. 2002 56:371-402 Electron micrographs of West Nile virus isolated from brain tissue from a crow found in New York *from CDC Website Common Symptoms of WNV |
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biology.science.oregonstate.edu
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biology.science.oregonstate.edu/helnwein
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| 25. 12月 2004 | Oregon State University | Biology Program Information | |
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biology.science.oregonstate.edu/PDFs/march1.pdf
